Journal of Cancer Stem Cell Research

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Securin: A Novel Stem/Cancer Stem Cell Marker

Journal of Cancer Stem Cell Research


Cancer stem cells—the rare cell populations with indefinite proliferative potential and ability to drive the formation and
growth of tumors are identified in solid tumors. These cells are known as cancer initiating cells and are capable for self-renewal.
These cells are reported to be responsible for drug resistance leading to tumor relapse and recurrence of cancer. It remains
unknown howand from where these cells originate. Since, cancer stem cells (CSCs) sharecommonmarkers and the ability to selfrenew-
with normal stem cells, it strongly suggests that CSCs might arise from normal stem cells. Several oncogenes are at the
epicenter for this phenomenon of putative transformation, formation of precancerous lesions and its subsequent clinical
manifestation into mature cancer. While several of these oncogenes are reported to be overexpressed in CSCs, our group
has extensively studied 'securin' alias 'pituitary tumor transforming gene' (PTTG) as one of the putative oncogenes reportedly
overexpressed in almost all the tumors including ovarian tumors studied to date. It is a multi-domain and multifunctional protooncogene,
and plays critical role in separation of sister chromatids during cell division. Its overexpression is linked to cellular
transformation, gene instability, aneuploidy, tumor progression, invasion, metastasis, cancer recurrence and oncotherapy
resistance. In our studies, we demonstrated co-expression of securin with several stem cell/cancer stem cell markers, pluripotent
and germ stem cell markers in normal ovary, various stages of ovarian tumor (Benign, Borderline and High Grade), and in ascites
cells collected from patients with recurrent ovarian cancer. Knockout of securin in ovarian cancer cell line (A2780) showed
regulation of expression of several stem/cancer stem cell markers, and regulation of self-renewal signaling pathways including
Notch1, WNT1/b-catenin and SHH. From our results, we conclude that securin is a novel stem/cancer stem cell marker and plays
important role in regulation of stem/cancer stem cell population.


Pranela Rameshwar, Ph.D.
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Mariusz Ratajczak, M.D., Ph.D. ...
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Justin Lathia, Ph.D.
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